[Free PDF.Emx8] Oxidative Stress and Vascular Disease (Developments in Cardiovascular Medicine)
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One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time. Primary Prevention of Cardiovascular Disease with a ... Original Article. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. Ramn Estruch M.D. Ph.D. Emilio Ros M.D. Ph.D. Jordi Salas-Salvad ... Cardiology Online - International Academy of Cardiology Cardiology Online is a cardiology guide and directory for congresses meetings and publications on heart disease and heart failure of the International Academy of ... ACSM Blog - The American College of Sports Medicine ACSM Blog; Position Stands; Team Physician Consensus Conference Statements; Roundtables ; ACSM Journals; Books & Multimedia; Sports Medicine Basics; Sports Medicine ... Free radicals antioxidants and functional foods: Impact ... Free radicals antioxidants and functional foods: Impact on human health V Lobo A Patil A Phatak N Chandra Department of Botany Birla College Kalyan - 421 304 ... Kidney International Kidney International (KI) is the official journal of the International Society of Nephrology. Under the editorial leadership of Dr. Detlef O. Schlndorff (USA) KI ... Peripartum Cardiomyopathy: Overview Etiopathophysiology ... Peripartum cardiomyopathy (PPCM) has a number of definitions but the authors prefer to use the one put forth by the Heart Failure Association of the ... Dr. Calapai's Nutritional Medicine practice: Prolotherapy ... Watch Dr. Calapai's new TV Show "Dr. Cal's Healthy Living" every Saturday 11:30 AM on channel 55 or 10 locally and America 1 Nationally Exploring the Factors That Affect Blood Cholesterol and ... Exploring the Factors That Affect Blood Cholesterol and Heart Disease Risk: Is Dietary Cholesterol as Bad for You as History Leads Us to Believe? 1 2 Home - PubMed - NCBI PubMed comprises more than 26 million citations for biomedical literature from MEDLINE life science journals and online books. Citations may include links ... Telmisartan Ramipril or Both in Patients at High Risk ... Original Article. Telmisartan Ramipril or Both in Patients at High Risk for Vascular Events. The ONTARGET Investigators * N Engl J Med 2008; 358:1547-1559 April 10 ...
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